Both lost in the opening round of the at the Stella Artois Championships.
Andre Agassi retained his majestic touch to crush German Rainer Schuettler 6-3, 6-1, 6-0 in Melbourne.
Andre Agassi was swept aside 6-4, 6-2 by Russian Nikolay Davydenko at the Masters Cup
The second seed was shocked by seventh seeded Argentinian Guillermo Coria in the quarter-finals of the French Open.
The World number ones were named top seeds for next week's U.S. Open.
Andre Agassi beat Andrei Pavel of Romania 6-7, 7-6, 7-6, 6-2 in the US Open first round.
The American former world number one, who retired in 2006, said his first steps into coaching were "challenging, interesting and educational".
Defending champion Tommy Hass also moved into the second round at the US Clay Court Championships.
Agassi was beaten by Chilean Fernando Gonzalez while Roddick lost to Tim Henman in the semis.
Carlos Alcaraz says winning all four Grand Slams at 22 has only fuelled his hunger, but the world No. 1 insists he won't chase a calendar Slam, choosing instead to take the majors one at a time.
Andre Agassi scored a 6-4, 7-6, 6-4 win over Italian Andreas Seppi in the second round
Tim Henman beat Andre Agassi in the first round of the Stella Artois Championships
Andre Agassi beat Greg Rusedski 7-6, 6-0 in the first round of the Dubai Open
The 35-year-old beat Brazilian Ricardo Mello in the first round of the Delray Beach International.
The American ace lost 6-4, 6-2 to Guillermo Garcia-Lopez in his comeback tournament in Florida
As a result of yesterday's defeat, Lleyton Hewitt of\nAustralia will replace Agassi at the top when the rankings.
Mardy Fish quit in the third set because of a back injury, allowing Andre Agassi to advance to the second round.
Former tennis champions Andre Agassi and Steffi Graf are to invest in and advise Europe's leading secondary ticketing company Viagogo to help it expand, the group said on Wednesday.
The victory gave Agassi a record six Key Biscayne titles.
The Las Vegan waved farewell to the event he won in 1992 with a sad smile and a lump in his throat
Andre Agassi has pulled out of this week's Legg Mason Tennis Classic in Washington to preserve energy for the U.S. Open.
The top seed powered into the semi-finals of the Los Angeles Open with a 6-2, 4-6, 6-4 win over Paradorn Srichaphan.
Andre Agassi headlined a list of nominees for the International Tennis Hall of Fame following a sparkling career highlighted by eight Grand Slam titles and an Olympic gold medal.
No official reason was given for Andre Agassi pulling out of the Canadian Open.
Andre Agassi rallied from a set down to edge out Alex Calatrava and advance to the quarterfinals in Houston
Andre Agassi lost 6-4, 6-3 to Italian qualifier Andrea Stoppini in the Legg Mason Tennis Classic second round.
Novak Djokovic will keep Andre Agassi as his head coach when he returns to action after recovering from an elbow injury which forced him to cut short his season in July, Serbia's former world number one said on Tuesday.
