The World number ones were named top seeds for next week's U.S. Open.
Andre Agassi beat Andrei Pavel of Romania 6-7, 7-6, 7-6, 6-2 in the US Open first round.
Defending champion Tommy Hass also moved into the second round at the US Clay Court Championships.
Agassi was beaten by Chilean Fernando Gonzalez while Roddick lost to Tim Henman in the semis.
'I've seen Federer and Nadal and they played a couple of good finals but nothing comes close to this.'
Andre Agassi scored a 6-4, 7-6, 6-4 win over Italian Andreas Seppi in the second round
Tim Henman beat Andre Agassi in the first round of the Stella Artois Championships
Andre Agassi beat Greg Rusedski 7-6, 6-0 in the first round of the Dubai Open
The American ace lost 6-4, 6-2 to Guillermo Garcia-Lopez in his comeback tournament in Florida
The 35-year-old beat Brazilian Ricardo Mello in the first round of the Delray Beach International.
As a result of yesterday's defeat, Lleyton Hewitt of\nAustralia will replace Agassi at the top when the rankings.
Former tennis champions Andre Agassi and Steffi Graf are to invest in and advise Europe's leading secondary ticketing company Viagogo to help it expand, the group said on Wednesday.
Mardy Fish quit in the third set because of a back injury, allowing Andre Agassi to advance to the second round.
The victory gave Agassi a record six Key Biscayne titles.
The Las Vegan waved farewell to the event he won in 1992 with a sad smile and a lump in his throat
Andre Agassi headlined a list of nominees for the International Tennis Hall of Fame following a sparkling career highlighted by eight Grand Slam titles and an Olympic gold medal.
Novak Djokovic will keep Andre Agassi as his head coach when he returns to action after recovering from an elbow injury which forced him to cut short his season in July, Serbia's former world number one said on Tuesday.
No official reason was given for Andre Agassi pulling out of the Canadian Open.
Andre Agassi has pulled out of this week's Legg Mason Tennis Classic in Washington to preserve energy for the U.S. Open.
The top seed powered into the semi-finals of the Los Angeles Open with a 6-2, 4-6, 6-4 win over Paradorn Srichaphan.
Andre Agassi rallied from a set down to edge out Alex Calatrava and advance to the quarterfinals in Houston
Andre Agassi lost 6-4, 6-3 to Italian qualifier Andrea Stoppini in the Legg Mason Tennis Classic second round.
We will look at alternatives if Dhoni doesn't deliver: Prasad
Learner Tien became the youngest man to reach the Australian Open fourth round in 20 years
'These guys, they can do everything I did on a return, except they have even a little more coverage'
It was like old times at Arthur Ashe Stadium as US Open fans gave Andre Agassi a rousing ovation as the former champion was honoured before Monday's opening night programme at Flushing Meadows.
Tennis star Andre Agassi's disclosure that he took a drug known as crystal meth and got away with it, is only one of the startling revelations in a new autobiography. Agassi also revealed that it was sport that he didn't choose and couldn't escape from.
Novak Djokovic says the decision to begin working with Andre Agassi came after he realised something had to change if he was to maintain a level of success throughout his career.
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